dic(9;16)(p13;q11) PAX5/?
نویسندگان
چکیده
منابع مشابه
Deregulated expression of PAX5 in medulloblastoma.
Medulloblatoma is a pediatric brain tumor originating in the human cerebellum. A collection of 23 medulloblastomas was analyzed for expression of the developmental control genes of the PAX and EN gene families by RNase protection and in situ hybridization. Of all nine PAX genes investigated, only PAX5 and PAX6 were consistently expressed in most medulloblastomas (70 and 78% of all cases, respec...
متن کاملOverexpression of PAX5 in oral carcinogenesis.
The oncogenic transcription factor PAX5 is an important developmental regulator and is implicated in the pathogenesis of several malignancies. The PAX5 gene is involved in medulloblastoma, non-Hodgkin's lymphoma, transitional cell carcinoma of the bladder, neuroblastoma, breast cancer and SCC. In the current study, to determine the potential involvement of PAX5 in oral squamous-cell carcinoma (...
متن کاملThe Role of PAX5 in ALL
It is now widely acknowledged that, like other cancers, acute lymphoblastic leukaemia is caused by the acquisition of mutations in somatic cells. The first hit in childhood ALL has been documented to occur in most (if not all) cases before birth (Golub, 2007). The progress in genomics technology holds the promise of making the complete characterization of the ‘cancer genome’ possible by a syste...
متن کاملA Novel Pax5-Binding Regulatory Element in the Igκ Locus
The Igκ locus undergoes a variety of different molecular processes during B cell development, including V(D)J rearrangement and somatic hypermutations (SHM), which are influenced by cis regulatory regions (RRs) within the locus. The Igκ locus includes three characterized RRs termed the intronic (iEκ), 3'Eκ, and Ed enhancers. We had previously noted that a region of DNA upstream of the iEκ and m...
متن کاملTranscriptional inhibition of intestinal NHE8 expression by glucocorticoids involves Pax5.
Sodium/hydrogen exchangers (NHEs) are a family of proteins that transport sodium ions into the cells by moving protons out of the cells. They play a major role in sodium absorption, cell volume regulation, and intracellular pH regulation. Three out of nine identified NHEs (NHE2, NHE3, and NHE8) are expressed on the apical membrane of intestinal epithelial cells. Glucocorticoids have been found ...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2014
ISSN: 1768-3262
DOI: 10.4267/2042/54375